Learn more about the product and see instructions on how to use it.

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About Hydrozid®

Hydrozid® combines traditional cryotherapy and modern aerosol technology. Hydrozid® provides instant, safe, and effective treatment of lentigo and a wide range of additional skin lesions. Hydrozid® comes with a patented delivery system, contained in the spray head. The spray head was developed to ensure that a consistent, controlled spray is delivered every time. Hydrozid® contains the gas norflurane (R134a), which has been used in asthma inhalers for many years and is proven to be safe. Hydrozid® was developed by a family-owned pharmaceutical and medical device company in Denmark. It has been used successfully throughout Europe since 2013.


When applied to the skin surface, Hydrozid® generates temperatures between -58°F (-50°C) and -65.2°F (-54°C). This is well below the temperatures that result in cell death. The formation of intra- and extracellular ice crystals destroys the top layer of skin – without damaging the healthy tissue. Effective treatment is achieved through repeated freeze-thaw cycles. The procedure is very brief, effective, and patient friendly.

Instructions for use

Important: Hydrozid® should only be used by healthcare professionals

Step 1

Hydrozid® is applied to a lesion directly from the canister. Hydrozid® does not require any preparation time; no foam tipped applicators, tubes, replacing spent cartridges.

Step 2

Move the lock extension to the right to open the spray head. Hydrozid® is applied to a lesion directly from the canister. No anesthesia prior to treatment is required.

Step 3

Hydrozid® is now ready to use. To avoid damaging the surrounding tissue use one of the application templates provided in the Hydrozid® pack. Select the hole matching the size of the individual lesion. Freeze the lesion by applying Hydrozid® from a distance of 2 to 3 cm followed by a complete thaw.

After a short interval, repeat the freeze-thaw cycle. Several repeated freeze-thaw cycles are recommended as in a single treatment. The total duration of application to a lesion must be kept within the recommended maximum total. For large lesions, it is recommended to apply the jet in circular movements from the centre of the lesion toward the edge.

pdf icon Download the Instruction For Use (PDF)

Treatment Times

The treatment time varies from one patient to another and depends partly on the location, thickness and appearance of the lesion as well as the patient’s skin type, age and other individual considerations. We always recommend making your own assessment on how to treat the specific plantar wart and only regard the treatment times as general guidelines.


See the Instructions For Use for details on indications, contraindications, warnings, and cautions.

Indication Recommended freeze-thaw cycle time Total recommended freeze time
Acrochordon (skin tag) 2x3 to 2x6 seconds 6 to 12 seconds
Actinic Keratosis (Facial & Non-Facial) 2x4 to 2x5 seconds 8 to 10 seconds
Seborrheic Keratosis 2x6 to 3x6 seconds 12 to 18 seconds
Lentigo (Facial & Non-Facial) 2x3 seconds 6 seconds
Molluscum Contagiosum 2x3 to 2x6 seconds 6 to 12 seconds
Verruca Plana 6x3 seconds 18 seconds
Verruca Plantaris 4x6 to 6x6 seconds 24 to 36 seconds
Verruca Vulgaris 4x6 to 6x6 seconds 24 to 36 seconds
Dermatofibroma 1x5-10 seconds 5 to 10 seconds
Small keloids 2x5-10 seconds 10 to 20 seconds
Granuloma annulare 2x5-10 seconds 10 to 20 seconds
Porokeratosis plantaris 2x5 seconds 10 seconds
Angiomas 2x5 seconds 10 seconds
Keratoacanthoma N/A N/A
Chondrodermatitis 2x5 seconds 10 seconds
Epithelial nevus 2x10 seconds 20 seconds
Leukoplakia N/A N/A
Granuloma pyogenicum 2x10 seconds 20 seconds

CPT Codes

Due to a wide range of reimbursement schedules, it is recommended that the following American Medical Association CPT Codes are used. The CPT codes and procedures may vary from time to time, carrier to carrier and are ultimately left up to the physician to interpret.

Acrochordon Up to 15 lesions CPT 11200
Additional lesions CPT 11201
Actinic keratosis One actinic keratosis CPT 17000
2 to 14 actinic keratoses CPT 17003
15 or more actinic keratoses CPT 17004
Age Spots (solar lentigines) One to 14 age spots CPT 17110
15 or more age spots CPT 17111
Angiomas Less than 10 cm CPT 17106
10-50 cm CPT 17107
Chondrodermatitis CPT 17000
Dermatofibroma One dermatofibroma CPT 17000
2 to 14 dermatofibromas CPT 17003
15 or more dermatofibromas CPT 17004
Epithelial nevus CPT 17110
Granuloma annulare CPT 17110
Granuloma pyogenicum CPT 17110
Keratoacanthoma CPT 17110
Leukoplakia CPT 17110
Molluscum contagiosum One to 14 lesions CPT 17110
15 or more lesions CPT 17111
Plantar warts One to 14 lesions CPT 17110
15 or more lesions CPT 17111
Porokeratosis plantaris CPT 17110
Pyogenic granuloma CPT 17110
Seborrheic keratosis One seborrheic keratosis CPT 17000
2 to 14 seborrheic keratoses CPT 17003
15 or more seborrheic keratoses CPT 17004
Small keloid CPT 17000

Before & After Treatment Results

Tap the spray can below to see Hydrozid in action.

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A patient’s Age Spots (Lentigo) before treatment.